FASCINATION ABOUT SIKIK

The perform of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which plays a crucial regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and influences most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also boost most